منابع مشابه
New tricks for KDEL receptors
The function of KDEL receptors (KDELR) is to capture endoplasmic reticulum (ER)-resident chaperones in the acidic environment of the Golgi apparatus, by recognizing their C-terminal motif, and retrieve them back to the ER [1]. Certain structural features of KDELR, for example a similar topology to that of G-protein-coupled receptors (GPCR), a large family of proteins involved in virtually all p...
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Learning and memory depend on persistent changes in synaptic strength that require neuronal gene expression. An unresolved question concerns the mechanisms by which activity at synapses is transduced into a nuclear transcriptional response. In the prevailing view, N-methyl-D-aspartate (NMDA)- and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors have disti...
متن کاملA molecular specificity code for the three mammalian KDEL receptors
AC-terminal KDEL-like motif prevents secretion of soluble endoplasmic reticulum (ER)-resident proteins. This motif interacts with KDEL receptors localized in the intermediate compartment and Golgi apparatus. Such binding triggers retrieval back to the ER via a coat protein I-dependent pathway. To date, two human KDEL receptors have been reported. Here, we report the Golgi localization of a thir...
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tively referred to as “old dogs.” In some instances, the designation may be a term of endearment: in others, a term of derision. Virtually every chairperson must face the dilemma of dealing with these senior staff members. His or her decision will be based primarily on how productive the senior radiologist is. I have had the unique opportunity to practice radiology over the past 27 years in bot...
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In This Issue In This Issue New tricks for old neurons Cytoplasmic p21 (green) promotes neu-rite outgrowth. ewborns seem to do much better than adults in healing injuries to their central nervous systems. At the cellular level, this is because inhibitory molecules in the adult central nervous system prevent neurons from extending their axons and dendrites, but the neurons in embryos and newborn...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.5444